منابع مشابه
FACTOR V AND VIII INHIBITOR IN PATIENTS WITH COMBINED FACTOR V AND VIII DEFICIENCY
Patients with coagulation factor(s) deficiency who use coagulation therapy are susceptible to forming inhibitors against coagulation factor(s). In this survey we detected factor V and VIII inhibitor in ten patients with combined deficiency of factors V and VIII from north east of Iran (Khorassan province). It was revealed in our survey that eight patients had both factor V and factor VIII i...
متن کاملCombined Factor V and VIII Deficiency
This review summarizes current data on the pathomechanisms and new genetic findings of combined factor V and VIII deficiency (CF5F8D). Congenital haemorrhagic disorders characterized by deficiency of two clotting factors comprise an interesting group. Among dual coagulation disorders, CF5F8D is the most common type. For the first time combined factor V and VIII deficiency (F5F8D) was reported b...
متن کاملFIXing factor VIII inhibitors.
2007;25(11):1315-1321. 6. Wei J, Wunderlich M, Fox C, et al. Microenvironment determines lineage fate in a human model of MLL-AF9 leukemia. Cancer Cell. 2008;13(6):483-495. 7. Han JH, Choi SJ, Kurihara N, Koide M, Oba Y, Roodman GD. Macrophage inflammatory protein-1alpha is an osteoclastogenic factor in myeloma that is independent of receptor activator of nuclear factor kappaB ligand. Blood. 20...
متن کاملAcquired factor VIII inhibitor.
PERSISTENT or uncontrolled bleeding is one of the most feared consequences of any surgical procedure. Numerous factors can contribute to its etiology. Among these, both inherited and acquired disorders of coagulation and/or thrombocyte function need to be taken into account. Acquired hemophilia can be caused by antibodies to coagulation factors. Antibodies can arise in hemophilic or nonhemophil...
متن کاملMutations of Factor VIII
Hemophilia A is caused by a defect in coagulation factor VIII, a protein that undergoes extensive proteolysis during its activation and inactivation. To determine whether some cases of hemophilia are caused by mutations in important cleavage sites, we screened patient DNA samples for mutations in these sites by a two-step process. Regions of interest were amplified from genomic DNA by repeated ...
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ژورنال
عنوان ژورنال: Nature Biotechnology
سال: 1991
ISSN: 1087-0156,1546-1696
DOI: 10.1038/nbt0491-327